Synthesis of 3-methylflavones and their antioxidant and antibacterial activities

B. S. Jayashree; Afroze Alam; Yogendra Nayak; D. Vijay Kumar

doi:10.1007/s00044-011-9725-y

Synthesis of 3-methylflavones and their antioxidant and antibacterial activities

B. S. Jayashree, Afroze Alam, Yogendra Nayak, D. Vijay Kumar

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

An attempt was made to synthesise newer 3-methylflavones with various substitution on the ring A and B of 2-phenylchromen-4-one. They were evaluated for antioxidant activity and antibacterial activity against the Gram-positive and Gram-negative bacteria. Five test compounds exhibited DPPH radical scavenging activity with IC50 below 100 lg/ml, and the same test compounds exhibited 50-100% growth inhibition in Gram-positive bacteria against standard Amoxicillin.

Original language	English
Pages (from-to)	1991-1996
Number of pages	6
Journal	Medicinal Chemistry Research
Volume	21
Issue number	8
DOIs	https://doi.org/10.1007/s00044-011-9725-y
Publication status	Published - 08-2012

All Science Journal Classification (ASJC) codes

Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

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title = "Synthesis of 3-methylflavones and their antioxidant and antibacterial activities",

abstract = "An attempt was made to synthesise newer 3-methylflavones with various substitution on the ring A and B of 2-phenylchromen-4-one. They were evaluated for antioxidant activity and antibacterial activity against the Gram-positive and Gram-negative bacteria. Five test compounds exhibited DPPH radical scavenging activity with IC50 below 100 lg/ml, and the same test compounds exhibited 50-100% growth inhibition in Gram-positive bacteria against standard Amoxicillin.",

author = "Jayashree, {B. S.} and Afroze Alam and Yogendra Nayak and {Vijay Kumar}, D.",

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AU - Nayak, Yogendra

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AB - An attempt was made to synthesise newer 3-methylflavones with various substitution on the ring A and B of 2-phenylchromen-4-one. They were evaluated for antioxidant activity and antibacterial activity against the Gram-positive and Gram-negative bacteria. Five test compounds exhibited DPPH radical scavenging activity with IC50 below 100 lg/ml, and the same test compounds exhibited 50-100% growth inhibition in Gram-positive bacteria against standard Amoxicillin.

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JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

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ER -

Synthesis of 3-methylflavones and their antioxidant and antibacterial activities

Abstract

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