Synthesis of 3-methylflavones and their antioxidant and antibacterial activities

B. S. Jayashree; Afroze Alam; Yogendra Nayak; D. Vijay Kumar

doi:10.1007/s00044-011-9725-y

Synthesis of 3-methylflavones and their antioxidant and antibacterial activities

B. S. Jayashree^*
, Afroze Alam
, Yogendra Nayak
, D. Vijay Kumar

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

An attempt was made to synthesise newer 3-methylflavones with various substitution on the ring A and B of 2-phenylchromen-4-one. They were evaluated for antioxidant activity and antibacterial activity against the Gram-positive and Gram-negative bacteria. Five test compounds exhibited DPPH radical scavenging activity with IC50 below 100 lg/ml, and the same test compounds exhibited 50-100% growth inhibition in Gram-positive bacteria against standard Amoxicillin.

Original language	English
Pages (from-to)	1991-1996
Number of pages	6
Journal	Medicinal Chemistry Research
Volume	21
Issue number	8
DOIs	https://doi.org/10.1007/s00044-011-9725-y
Publication status	Published - 08-2012

All Science Journal Classification (ASJC) codes

Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

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10.1007/s00044-011-9725-y

Cite this

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title = "Synthesis of 3-methylflavones and their antioxidant and antibacterial activities",

abstract = "An attempt was made to synthesise newer 3-methylflavones with various substitution on the ring A and B of 2-phenylchromen-4-one. They were evaluated for antioxidant activity and antibacterial activity against the Gram-positive and Gram-negative bacteria. Five test compounds exhibited DPPH radical scavenging activity with IC50 below 100 lg/ml, and the same test compounds exhibited 50-100\% growth inhibition in Gram-positive bacteria against standard Amoxicillin.",

author = "Jayashree, \{B. S.\} and Afroze Alam and Yogendra Nayak and \{Vijay Kumar\}, D.",

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AU - Jayashree, B. S.

AU - Alam, Afroze

AU - Nayak, Yogendra

AU - Vijay Kumar, D.

PY - 2012/8

Y1 - 2012/8

N2 - An attempt was made to synthesise newer 3-methylflavones with various substitution on the ring A and B of 2-phenylchromen-4-one. They were evaluated for antioxidant activity and antibacterial activity against the Gram-positive and Gram-negative bacteria. Five test compounds exhibited DPPH radical scavenging activity with IC50 below 100 lg/ml, and the same test compounds exhibited 50-100% growth inhibition in Gram-positive bacteria against standard Amoxicillin.

AB - An attempt was made to synthesise newer 3-methylflavones with various substitution on the ring A and B of 2-phenylchromen-4-one. They were evaluated for antioxidant activity and antibacterial activity against the Gram-positive and Gram-negative bacteria. Five test compounds exhibited DPPH radical scavenging activity with IC50 below 100 lg/ml, and the same test compounds exhibited 50-100% growth inhibition in Gram-positive bacteria against standard Amoxicillin.

UR - https://www.scopus.com/pages/publications/84866088250

UR - https://www.scopus.com/pages/publications/84866088250#tab=citedBy

U2 - 10.1007/s00044-011-9725-y

DO - 10.1007/s00044-011-9725-y

M3 - Article

AN - SCOPUS:84866088250

SN - 1054-2523

VL - 21

SP - 1991

EP - 1996

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

IS - 8

ER -

Synthesis of 3-methylflavones and their antioxidant and antibacterial activities

Abstract

All Science Journal Classification (ASJC) codes

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