TY - JOUR
T1 - Synthesis of Ca-doped ZnO nanoparticles and its application as highly efficient electrochemical sensor for the determination of anti-viral drug, acyclovir
AU - Ilager, Davalasab
AU - Shetti, Nagaraj P.
AU - Malladi, Ramesh S.
AU - Shetty, Nitinkumar S.
AU - Reddy, Kakarla Raghava
AU - Aminabhavi, Tejraj M.
N1 - Publisher Copyright:
© 2020
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2021/1/15
Y1 - 2021/1/15
N2 - Recent developments to utilize nanostructured metal oxides for fabricating novel sensors with superior sensitivity have prompted advanced detection limits even at trace level. In the current study, development of calcium doped zinc oxide (Ca-ZnO) nanoparticles as a novel electroanalytical sensing tool for the detection of antiviral drug, acyclovir (ACV) was performed. Ca-ZnO nanoparticles modified sensors to enhance the electrochemical properties of ACV as compared to an unmodified glassy carbon electrode (GCE) in pH 5.0. The influence of various factors such as effect of pre-concentration time, sweep rate, and concentration on the oxidation peak current of ACV has been discussed. The experimental results showed the wide linearity range (8.0 × 10−8 M to 2.4 × 10−5 M) with lower values of detection (6.18 nM). Hence, developed novel nanosensor showed an intensification of peak current of ACV with significant sensitivity, selectivity, and reproducibility for ACV analysis and obtained results were apply for the determination of ACV in the analysis of urine and pharmaceutical dosage form.
AB - Recent developments to utilize nanostructured metal oxides for fabricating novel sensors with superior sensitivity have prompted advanced detection limits even at trace level. In the current study, development of calcium doped zinc oxide (Ca-ZnO) nanoparticles as a novel electroanalytical sensing tool for the detection of antiviral drug, acyclovir (ACV) was performed. Ca-ZnO nanoparticles modified sensors to enhance the electrochemical properties of ACV as compared to an unmodified glassy carbon electrode (GCE) in pH 5.0. The influence of various factors such as effect of pre-concentration time, sweep rate, and concentration on the oxidation peak current of ACV has been discussed. The experimental results showed the wide linearity range (8.0 × 10−8 M to 2.4 × 10−5 M) with lower values of detection (6.18 nM). Hence, developed novel nanosensor showed an intensification of peak current of ACV with significant sensitivity, selectivity, and reproducibility for ACV analysis and obtained results were apply for the determination of ACV in the analysis of urine and pharmaceutical dosage form.
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U2 - 10.1016/j.molliq.2020.114552
DO - 10.1016/j.molliq.2020.114552
M3 - Article
AN - SCOPUS:85095838995
SN - 0167-7322
JO - Journal of Molecular Liquids
JF - Journal of Molecular Liquids
M1 - 114552
ER -