Synthesis of carboxamides of 2′-amino-4′-(6-bromo-3-coumarinyl) thiazole as analgesic and antiinflammatory agents

A series of carboxamides of 2′-amino-4′-(6-bromo-3-coumarinyl)- thiazole were synthesized, purified and characterized on the basis of spectral data such as IR, ¹H NMR and mass spectral (MS) studies and were subjected to analgesic and antiinflammatory activity by acetic acid induced abdominal constriction method and carrageenan induced rat hind paw oedema method respectively. Out of the compounds tested, few showed significant analgesic and antiinflammatory activity.