Synthesis of carboxamides of 2′-amino-4′-(6-bromo-3-coumarinyl) thiazole as analgesic and antiinflammatory agents

K. N. Venugopala; B. S. Jayashree

Synthesis of carboxamides of 2′-amino-4′-(6-bromo-3-coumarinyl) thiazole as analgesic and antiinflammatory agents

K. N. Venugopala^*
, B. S. Jayashree

^*Corresponding author for this work

Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

A series of carboxamides of 2′-amino-4′-(6-bromo-3-coumarinyl)- thiazole were synthesized, purified and characterized on the basis of spectral data such as IR, ¹H NMR and mass spectral (MS) studies and were subjected to analgesic and antiinflammatory activity by acetic acid induced abdominal constriction method and carrageenan induced rat hind paw oedema method respectively. Out of the compounds tested, few showed significant analgesic and antiinflammatory activity.

Original language	English
Pages (from-to)	307-310
Number of pages	4
Journal	Indian Journal of Heterocyclic Chemistry
Volume	12
Issue number	4
Publication status	Published - 01-04-2003

All Science Journal Classification (ASJC) codes

Organic Chemistry

Cite this

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abstract = "A series of carboxamides of 2′-amino-4′-(6-bromo-3-coumarinyl)- thiazole were synthesized, purified and characterized on the basis of spectral data such as IR, 1H NMR and mass spectral (MS) studies and were subjected to analgesic and antiinflammatory activity by acetic acid induced abdominal constriction method and carrageenan induced rat hind paw oedema method respectively. Out of the compounds tested, few showed significant analgesic and antiinflammatory activity.",

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AU - Jayashree, B. S.

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N2 - A series of carboxamides of 2′-amino-4′-(6-bromo-3-coumarinyl)- thiazole were synthesized, purified and characterized on the basis of spectral data such as IR, 1H NMR and mass spectral (MS) studies and were subjected to analgesic and antiinflammatory activity by acetic acid induced abdominal constriction method and carrageenan induced rat hind paw oedema method respectively. Out of the compounds tested, few showed significant analgesic and antiinflammatory activity.

AB - A series of carboxamides of 2′-amino-4′-(6-bromo-3-coumarinyl)- thiazole were synthesized, purified and characterized on the basis of spectral data such as IR, 1H NMR and mass spectral (MS) studies and were subjected to analgesic and antiinflammatory activity by acetic acid induced abdominal constriction method and carrageenan induced rat hind paw oedema method respectively. Out of the compounds tested, few showed significant analgesic and antiinflammatory activity.

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M3 - Article

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SN - 0971-1627

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ER -

Synthesis of carboxamides of 2′-amino-4′-(6-bromo-3-coumarinyl) thiazole as analgesic and antiinflammatory agents

Abstract

All Science Journal Classification (ASJC) codes

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