TY - JOUR
T1 - Synthesis of new series of 5,6-dihydro-4H-1,2-oxazines via hetero Diels-Alder reaction and evaluation of antimicrobial activity
AU - Manjula, M. K.
AU - Rai, K. M.L.
AU - Gaonkar, S. L.
AU - Raveesha, K. A.
AU - Satish, S.
PY - 2009/1
Y1 - 2009/1
N2 - A new series of 5,6-dihydro-4H-1,2-oxazines were synthesized via hetero Diels-Alder reaction of α-nitrosoolefins with alkenes. α-Nitrosoolefins were generated from ketoximes by the action of chloramine-T. The newly synthesized compounds were characterized with IR, NMR, elemental analysis and screened for their antimicrobial activity; they exhibited excellent antimicrobial activity. The minimal inhibitory concentration of the compounds was in the range of 10-35 μg ml-1 for bacteria and 10-40 μg ml-1 for fungi.
AB - A new series of 5,6-dihydro-4H-1,2-oxazines were synthesized via hetero Diels-Alder reaction of α-nitrosoolefins with alkenes. α-Nitrosoolefins were generated from ketoximes by the action of chloramine-T. The newly synthesized compounds were characterized with IR, NMR, elemental analysis and screened for their antimicrobial activity; they exhibited excellent antimicrobial activity. The minimal inhibitory concentration of the compounds was in the range of 10-35 μg ml-1 for bacteria and 10-40 μg ml-1 for fungi.
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U2 - 10.1016/j.ejmech.2008.02.027
DO - 10.1016/j.ejmech.2008.02.027
M3 - Article
C2 - 18420309
AN - SCOPUS:57949092972
SN - 0223-5234
VL - 44
SP - 280
EP - 288
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
IS - 1
ER -