TY - JOUR
T1 - Synthesis of newer piperidinyl chalcones and their anticancer activity in human cancer cell lines
AU - Jayashree, B. S.
AU - Patel, Harshkumar H.
AU - Mathew, Neethu Susan
AU - Nayak, Yogendra
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Newer tetrahydropyridine chalcones were synthesized and tested for their antioxidant and anticancer activity. These molecules showed significant anticancer activity at IC50 < 50 μM in human cancer cell lines such as A549 (lung adenocarcinoma), HepG2 (hepatocellular liver carcinoma), HeLa (cervical cancer), HCT-116 (colon carcinoma cells), MCF-7 (breast cancer cell line), and MDA MB 231 (breast cancer cells) cancer cells. The test compounds significantly inhibited cancer cell migrations in scratch wound assay for angiogenesis. Further, the test compounds bearing naphthalene substituents on the main ring showed in vitro antioxidant activity at <100 μM by 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation, superoxide radical scavenging, O-phenonthroline, and lipid peroxidation assays. In conclusion, two test compounds bearing naphthalene substitutions exhibited potent anticancer activity that could be attributed to their ability to induce apoptosis, inhibit cancer cell migrations, provide anti-angiogenic properties, and also partly by reducing oxidative stress by scavenging free radicals.
AB - Newer tetrahydropyridine chalcones were synthesized and tested for their antioxidant and anticancer activity. These molecules showed significant anticancer activity at IC50 < 50 μM in human cancer cell lines such as A549 (lung adenocarcinoma), HepG2 (hepatocellular liver carcinoma), HeLa (cervical cancer), HCT-116 (colon carcinoma cells), MCF-7 (breast cancer cell line), and MDA MB 231 (breast cancer cells) cancer cells. The test compounds significantly inhibited cancer cell migrations in scratch wound assay for angiogenesis. Further, the test compounds bearing naphthalene substituents on the main ring showed in vitro antioxidant activity at <100 μM by 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation, superoxide radical scavenging, O-phenonthroline, and lipid peroxidation assays. In conclusion, two test compounds bearing naphthalene substitutions exhibited potent anticancer activity that could be attributed to their ability to induce apoptosis, inhibit cancer cell migrations, provide anti-angiogenic properties, and also partly by reducing oxidative stress by scavenging free radicals.
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U2 - 10.1007/s11164-015-2238-4
DO - 10.1007/s11164-015-2238-4
M3 - Article
AN - SCOPUS:84941330836
SN - 0922-6168
VL - 42
SP - 3673
EP - 3688
JO - Research on Chemical Intermediates
JF - Research on Chemical Intermediates
IS - 4
ER -
