Synthesis of some amino acids incorporated 4(3H)-quinazolinones as possible antiherpes viral agents

Anthranilic acid was refluxed with acetic anhydride and sodium acetate to form N-acetyl anthranilic acid. The acetylated product was cyclised to 4-(2-methy|-4-oxo-4H-quinazolin-3-yl)-benzoic acid (I) with p-aminobenzoic acid in the presence of phosphorous pentoxide and glacial acetic acid. The quinazolinone derivative so formed on reaction with thionyl chloride in the presence of 1,4-dioxan as solvent form the chloro derivative (II) which was then treated with different amino acids gave the title compounds, 4-(2-methyl-4oxo-4H-quinazolin-3yl)-benzoyl aminoacid derivatives (1-5). All the intermediates and title compounds were characterized by physical, chemical, analytical and spectral data. All the title compounds have been screened for their invitro cytotoxic and antiviral activities. Compound 5 showed potent antiviral activity.