Synthesis, spectroscopic and anti tumor studies on copper(II) complex of orthohydroxypropiophenoneisonicotinoylhydrazone

G. N. Ramesh, B. Prathima, Y. Subba Rao, Y. P. Reddy, K. S.R. Pai, A. Varada Reddy

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3 Citations (Scopus)


Orthohydroxypropiophenoneisonicotinoylhydrazone ligand(L) has been synthesized from orthohydroxypropiophenone and isonicotinicacid hydrazide. The Cu(II) complex is prepared and structurally characterized. The structure of the ligand(L) is proposed based on elemental analysis, IR and mass spectra and Cu(II) complex is characterized from the studies of electronic spectra, EPR spectra, powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). On the basis of electronic and EPR studies, rhombically distorted octahedral environment has been proposed for the Cu(II) ion. The powder X-ray diffraction data indicate triclinic structure with the unit cell parameters: a = 9.4734 Å, b = 6.1588 Å, c = 3.9254 Å, and V = 195.6 Å3 for the complex. The ligand and Cu(II) complex have been tested for in vitro antibacterial, antioxidant and cytotoxic activities. The results reveal that the Cu(II) complex exhibits greater activity than the free ligand.

Original languageEnglish
Pages (from-to)S404-S410
JournalArabian Journal of Chemistry
Publication statusPublished - 01-09-2016

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • General Chemical Engineering


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