TY - JOUR
T1 - Temperature and pH-responsive nanogels as intelligent drug delivery systems
T2 - A comprehensive review
AU - Jha, Adrija
AU - Rama, Annamalai
AU - Ladani, Bhautik
AU - Verma, Natasha
AU - Kannan, Sivakumar
AU - Naha, Anup
N1 - Funding Information:
The authors acknowledge the help of the Manipal College of Pharmaceutical Sciences and Manipal Academy of Higher Education for their support throughout the study.
Publisher Copyright:
© 2021. Adrija Jha et al. All Rights Reserved.
PY - 2021/12
Y1 - 2021/12
N2 - With the advancement of technology and the evolution of modern healthcare systems, the focus is shifting from conventional drug delivery vehicles to novel, nanosized carriers. Nanogels are an example of such nanosized drug delivery systems that have been researched at length. They can be designed to be sensitive to a multitude of physical and chemical stimuli and this endows them with the capability to deliver the drugs they carry in a site-specific manner. These intelligent drug delivery systems are biocompatible and capable of loading copious quantities of the drug. pH is a major chemical property and temperature is a major physical property of a biological system. So nanogels responsive to either pH or temperature or a combination of both, possess immense biomedical potential. This review encompasses synthetic techniques and evaluation tests to confirm the responsiveness of single pH-responsive nanogels and thermoresponsive nanogels as well as dual pH/thermoresponsive nanogels. A closer look is also taken at their biomedical applications.
AB - With the advancement of technology and the evolution of modern healthcare systems, the focus is shifting from conventional drug delivery vehicles to novel, nanosized carriers. Nanogels are an example of such nanosized drug delivery systems that have been researched at length. They can be designed to be sensitive to a multitude of physical and chemical stimuli and this endows them with the capability to deliver the drugs they carry in a site-specific manner. These intelligent drug delivery systems are biocompatible and capable of loading copious quantities of the drug. pH is a major chemical property and temperature is a major physical property of a biological system. So nanogels responsive to either pH or temperature or a combination of both, possess immense biomedical potential. This review encompasses synthetic techniques and evaluation tests to confirm the responsiveness of single pH-responsive nanogels and thermoresponsive nanogels as well as dual pH/thermoresponsive nanogels. A closer look is also taken at their biomedical applications.
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U2 - 10.7324/JAPS.2021.1101201
DO - 10.7324/JAPS.2021.1101201
M3 - Article
AN - SCOPUS:85122259779
SN - 2231-3354
VL - 11
SP - 1
EP - 16
JO - Journal of Applied Pharmaceutical Science
JF - Journal of Applied Pharmaceutical Science
IS - 12
ER -