TY - JOUR
T1 - Temporal cytokine storm dynamics in dengue infection predicts severity
AU - Bhatt, Puneet
AU - Varma, Muralidhar
AU - Sood, Vikas
AU - Ambikan, Anoop
AU - Jayaram, Anup
AU - Babu, Naren
AU - Gupta, Soham
AU - Mukhopadhyay, Chiranjay
AU - Neogi, Ujjwal
N1 - Publisher Copyright:
© 2024 The Author(s)
PY - 2024/3
Y1 - 2024/3
N2 - The immunopathogenesis of dengue severity is convoluted. The primary objective of the research was to examine the dynamics of cytokine storm and its correlation with disease development in individuals affected by DENV infection. Additionally, the study aimed to discover potential biomarkers that could indicate severe dengue infection and determine the most suitable timeframe for predicting the severity of these biomarkers during the acute stage of dengue infections. We conducted a temporal analysis of the daily viral load and cytokine levels in 60 hospitalized dengue patients until discharge. Our findings reveal a distinct cytokine profile (elevated IL-8, IL-10, IL-6, GM-CSF, MCP-1, IL-13, and IL-4 and decreased IL-12, MIP-1β) on the third day after symptom onset is predictive of severe dengue in secondary dengue infection. The imbalanced cytokine signature may inform clinical decision-making in treating severe dengue infections.
AB - The immunopathogenesis of dengue severity is convoluted. The primary objective of the research was to examine the dynamics of cytokine storm and its correlation with disease development in individuals affected by DENV infection. Additionally, the study aimed to discover potential biomarkers that could indicate severe dengue infection and determine the most suitable timeframe for predicting the severity of these biomarkers during the acute stage of dengue infections. We conducted a temporal analysis of the daily viral load and cytokine levels in 60 hospitalized dengue patients until discharge. Our findings reveal a distinct cytokine profile (elevated IL-8, IL-10, IL-6, GM-CSF, MCP-1, IL-13, and IL-4 and decreased IL-12, MIP-1β) on the third day after symptom onset is predictive of severe dengue in secondary dengue infection. The imbalanced cytokine signature may inform clinical decision-making in treating severe dengue infections.
UR - http://www.scopus.com/inward/record.url?scp=85181815737&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85181815737&partnerID=8YFLogxK
U2 - 10.1016/j.virusres.2023.199306
DO - 10.1016/j.virusres.2023.199306
M3 - Article
C2 - 38176525
AN - SCOPUS:85181815737
SN - 0168-1702
VL - 341
JO - Virus Research
JF - Virus Research
M1 - 199306
ER -
