TY - JOUR
T1 - Tenofovir disoproxil fumarate-induced distal renal tubular acidosis
T2 - A case report
AU - Salimi, Rozhin
AU - Begum, Ishmath
AU - Varma, Danturulu Muralidhar
AU - Nandakrishna, B.
AU - Rajesh, Radhakrishnan
AU - Vidyasagar, Sudha
N1 - Publisher Copyright:
© The Author(s) 2020.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Tenofovir disoproxil fumarate (TDF) is an anti-retroviral drug that is known to cause nephrotoxicity including renal tubular acidosis (RTA). With increasing literature on proximal RTA caused by TDF, reports on distal RTA are scarce, with only one case reported so far. We report a case of distal RTA in patient living with human immunodeficiency virus, who presented with nausea and fatigue giving a history of TDF-based therapy for two years. Laboratory investigations revealed non-anion gap metabolic acidosis, positive urine anion gap, hyperchloremia, and hypokalemia. The patient improved after discontinuing TDF and supportive management.
AB - Tenofovir disoproxil fumarate (TDF) is an anti-retroviral drug that is known to cause nephrotoxicity including renal tubular acidosis (RTA). With increasing literature on proximal RTA caused by TDF, reports on distal RTA are scarce, with only one case reported so far. We report a case of distal RTA in patient living with human immunodeficiency virus, who presented with nausea and fatigue giving a history of TDF-based therapy for two years. Laboratory investigations revealed non-anion gap metabolic acidosis, positive urine anion gap, hyperchloremia, and hypokalemia. The patient improved after discontinuing TDF and supportive management.
UR - http://www.scopus.com/inward/record.url?scp=85078750170&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85078750170&partnerID=8YFLogxK
U2 - 10.1177/0956462419887877
DO - 10.1177/0956462419887877
M3 - Article
C2 - 31996094
AN - SCOPUS:85078750170
SN - 0956-4624
VL - 31
SP - 276
EP - 279
JO - International Journal of STD and AIDS
JF - International Journal of STD and AIDS
IS - 3
ER -
