The Biology of Lung Cancer: Development of More Effective Methods for Prevention, Diagnosis, and Treatment

Ramin Salehi-Rad; Rui Li; Manash K. Paul; Steven M. Dubinett; Bin Liu

doi:10.1016/j.ccm.2019.10.003

The Biology of Lung Cancer: Development of More Effective Methods for Prevention, Diagnosis, and Treatment

Ramin Salehi-Rad, Rui Li, Manash K. Paul, Steven M. Dubinett^*, Bin Liu

^*Corresponding author for this work

Department of Radiation Biology and Toxicology, Manipal School of Life Sciences, Manipal

Research output: Contribution to journal › Review article › peer-review

69 Citations (Scopus)

Abstract

Lung cancer is a heterogeneous disease with abundant genomic alterations. Chronic dysregulated airway inflammation facilitates lung tumorigenesis. In contrast, antitumor host immune responses apply continuous selective pressure on the tumor cells during the evolutionary course of the disease. Unprecedented advances in integrative genomic, epigenomic, and cellular profiling of lung cancer and the tumor microenvironment are enhancing the understanding of pulmonary tumorigenesis. This understanding in turn has led to advancements in lung cancer prevention and early detection strategies, and the development of effective targeted therapies and immunotherapies with survival benefit in selected patients.

Original language	English
Pages (from-to)	25-38
Number of pages	14
Journal	Clinics in Chest Medicine
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/j.ccm.2019.10.003
Publication status	Published - 03-2020

All Science Journal Classification (ASJC) codes

Pulmonary and Respiratory Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ccm.2019.10.003

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title = "The Biology of Lung Cancer: Development of More Effective Methods for Prevention, Diagnosis, and Treatment",

abstract = "Lung cancer is a heterogeneous disease with abundant genomic alterations. Chronic dysregulated airway inflammation facilitates lung tumorigenesis. In contrast, antitumor host immune responses apply continuous selective pressure on the tumor cells during the evolutionary course of the disease. Unprecedented advances in integrative genomic, epigenomic, and cellular profiling of lung cancer and the tumor microenvironment are enhancing the understanding of pulmonary tumorigenesis. This understanding in turn has led to advancements in lung cancer prevention and early detection strategies, and the development of effective targeted therapies and immunotherapies with survival benefit in selected patients.",

author = "Ramin Salehi-Rad and Rui Li and Paul, \{Manash K.\} and Dubinett, \{Steven M.\} and Bin Liu",

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AU - Dubinett, Steven M.

AU - Liu, Bin

PY - 2020/3

Y1 - 2020/3

N2 - Lung cancer is a heterogeneous disease with abundant genomic alterations. Chronic dysregulated airway inflammation facilitates lung tumorigenesis. In contrast, antitumor host immune responses apply continuous selective pressure on the tumor cells during the evolutionary course of the disease. Unprecedented advances in integrative genomic, epigenomic, and cellular profiling of lung cancer and the tumor microenvironment are enhancing the understanding of pulmonary tumorigenesis. This understanding in turn has led to advancements in lung cancer prevention and early detection strategies, and the development of effective targeted therapies and immunotherapies with survival benefit in selected patients.

AB - Lung cancer is a heterogeneous disease with abundant genomic alterations. Chronic dysregulated airway inflammation facilitates lung tumorigenesis. In contrast, antitumor host immune responses apply continuous selective pressure on the tumor cells during the evolutionary course of the disease. Unprecedented advances in integrative genomic, epigenomic, and cellular profiling of lung cancer and the tumor microenvironment are enhancing the understanding of pulmonary tumorigenesis. This understanding in turn has led to advancements in lung cancer prevention and early detection strategies, and the development of effective targeted therapies and immunotherapies with survival benefit in selected patients.

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The Biology of Lung Cancer: Development of More Effective Methods for Prevention, Diagnosis, and Treatment

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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