@article{9d26f263a8d143e3876e346b4bd489d1,
title = "The effect of ethanol extract of Wrightia tinctoria bark on wound healing in rats",
abstract = "Objectives: To screen the wound healing activity of ethanol extract of Wrightia tinctoria bark using incision, excision and dead space wound models and evaluate histopathological and biochemical changes of granuloma tissue. Material and method: The bark powder of W. tinctoria was extracted with 95% ethanol by continuous heat extraction and was subjected for phytochemical investigation and screened for wound healing activity in the incision, excision and dead space wound models in rats. A supportive study made on granuloma tissue to estimate the hydroxyproline content and histopathological examination to determine the pattern of lay-down for collagen using Masson Trichrome stain. Results: Triterpenoids, steroids and saponins were found to be present in ethanol extract of the barks of W. tinctoria. In resutured incision wound model, ethanol extract showed significant breaking strength (P",
author = "V.P. Veerapur and M.B. Palkar and H. Srinivasa and M.S. Kumar and S. Patra and P.G.M. Rao and K.K. Srinivasan",
note = "Cited By :25 Export Date: 10 November 2017 CODEN: JNROA Correspondence Address: Veerapur, V.P.; Dept. of Pharmaceutical Chemistry, Manipal Coll. of Pharmaceut. Sci., Manipal-576 119 Karnataka, India; email: veeresh36@yahoo.com Chemicals/CAS: alcohol, 64-17-5; alpha amyrin, 638-95-9; beta amyrin, 559-70-6; collagen, 9007-34-5; gum tragacanth, 9000-65-1; hydroxyproline, 51-35-4, 6912-67-0; saponin, 8047-15-2 References: Warrier, P.K., Nambiar, V.P.K., Ramankutty, C., (1996) Indian Medicinal Plants, A Compendium of 500 Species, 5, pp. 417-419. , Vaidyanathum PS. (Eds.) Varier's Orient Longman Ltd: Madras; Nadkarni, K.M., (1982) Indian Materia Medica, 1, pp. 635-637. , Popular Prakashan: Bombay; Ramchandra, P., (1993) J. Natural Products, 56 (10), pp. 1811-1812; Rangaswami, S., Mangeswara Rao, M., (1963) Proc. Indian Acad. Sci., 57 A, pp. 115-120; Nesamony, S., (1993) Oushadha Sasyangal, pp. 175-176. , State Institute of Languages: Kerala; Harborne, J.B., (1998) Phytochemical Methods, pp. 60-66. , Chapman and Hall: London; Kaokate, C.K., (1991) Practical Pharmacognosy, pp. 107-112. , Vallabh Prakashan: Delhi; Ghosh, M.N., (1984) Fundamentals of Experimental Pharmacology, pp. 153-158. , 2nd Edn. Scientific book Agency: Culcutta; Ehrlich, H.P., Hunt, T.K., (1969) Ann. Surg., 170, pp. 203-206; Lee, K.H., (1968) J. Pharm. Sci., 57, pp. 1042-1047; Morton, J.J.P., Malone, M.H., (1972) Arch. Int. Pharmacodyn., 196, pp. 117-136; Patil, P.A., Kulkarni, D.R., (1984) Indian. J. Med. Res., 79, pp. 445-447; Schilling, A., (1968) J. Physiol. Rev., 48, pp. 374-375; Neuman, R.E., Logan, M.A., (1950) J. Biol. Chem., 186, pp. 549-552; Kulkarni, S.K., (1993) Hand Book of Experimental Pharmacology, pp. 85-96. , Vallabh Prakashan: Delhi; Tenni, R., (1988) Ital. J. Biochem., 37, pp. 69-77; Sunitha, S., Nagaraj, M., Varalakshmi, P., (2001) Fitoterapia, 72, pp. 516-523; Shobha, S.N., Gurumadhava Rao, S., (1999) Indian J. Physiol. Pharmacol., 43, pp. 230-234",
year = "2004",
language = "English",
volume = "4",
pages = "155--159",
journal = "Journal of Natural Remedies",
issn = "0972-5547",
publisher = "Natural Remedies Private Limited",
number = "2",
}