The Impact of Casirivimab-Imdevimab Antibody Cocktail in Patients Amidst and Post COVID 19 Treatment: A Retro-Prospective Comparative Study in India

Aneesh Puthiyedath Joy, Mohammed Salim Karattuthodi, Dilip Chandrasekher, Anitha Theresa Augustine

Research output: Contribution to journalArticlepeer-review

Abstract

Monoclonal antibodies have gained attention in developing countries owing to its benefits portrayed by few clinical trial. However, no studies until now have been undergone in India. MATERIAL: Aretro - prospective comparative observational study was conducted in symptomatic COVID19 patients to evaluate the impact of Casirivimab and Imdevimab antibody cocktail in the high-risk population. Through an extensive data retrieval for 6 months, 152 samples were documented and sorted into test (Casirivimab and Imdevimab treated patients, n=79) and control (Non- Casirivimab and Imdevimab treated individuals, n=73) subsets. The research had two phases; first, estimation of mechanical ventilation and high flow oxygen requirement and mortality in samples amidst the treatment, and second was the post COVID19 patients' feedback through validated (Cronbach's alpha coefficient= 0.7) questionnaire that evaluated their health and vaccination status, and treatment satisfaction. OBSERVATION: We noticed lesser requisite for mechanical ventilation (6.3%; p<0.001), high flow oxygen (5.1%; p<0.001) and no death during Casirivimab and Imdevimab therapy. Meanwhile, non-vaccinated test groups were not on mechanical ventilation and those fully immunized seldom entailed high flow oxygen (test, 6.3%; control, 41.9%, p<0.01). On evaluating the post COVID19 status of each patient in the study, 90.1% of the test samples were healthy and 97.2% were satisfied with the treatment than those in control group. CONCLUSION: Casirivimab and Imdevimab regimen was clinically beneficial for high risk COVID19 patients than those treated without the antibody cocktail.

Original languageEnglish
Pages (from-to)11-12
Number of pages2
JournalThe Journal of the Association of Physicians of India
Volume70
Issue number4
Publication statusPublished - 01-04-2022

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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