TY - JOUR
T1 - The Role of Calcium Signaling in Regulation of Epithelial-Mesenchymal Transition
AU - Adiga, Divya
AU - Radhakrishnan, Raghu
AU - Chakrabarty, Sanjiban
AU - Kumar, Prashant
AU - Kabekkodu, Shama Prasada
N1 - Funding Information:
Department of Science and Technology (DST), Science and Engineering Research Board (SERB) , Government of India (Grant No: EMR/2016/002314), , Department of Biotechnology (DBT), Government of India (6242-P8/RGCB/PMD/DBT/SPDK/2015).
Publisher Copyright:
© 2020 S. Karger AG, Basel. All rights reserved.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Despite substantial advances in the field of cancer therapeutics, metastasis is a significant challenge for a favorable clinical outcome. Epithelial to mesenchymal transition (EMT) is a process of acquiring increased motility, invasiveness, and therapeutic resistance by cancer cells for their sustained growth and survival. A plethora of intrinsic mechanisms and extrinsic microenvironmental factors drive the process of cancer metastasis. Calcium (Ca2+) signaling plays a critical role in dictating the adaptive metastatic cell behavior comprising of cell migration, invasion, angiogenesis, and intravasation. By modulating EMT, Ca2+ signaling can regulate the complexity and dynamics of events leading to metastasis. This review summarizes the role of Ca2+ signal remodeling in the regulation of EMT and metastasis in cancer.
AB - Despite substantial advances in the field of cancer therapeutics, metastasis is a significant challenge for a favorable clinical outcome. Epithelial to mesenchymal transition (EMT) is a process of acquiring increased motility, invasiveness, and therapeutic resistance by cancer cells for their sustained growth and survival. A plethora of intrinsic mechanisms and extrinsic microenvironmental factors drive the process of cancer metastasis. Calcium (Ca2+) signaling plays a critical role in dictating the adaptive metastatic cell behavior comprising of cell migration, invasion, angiogenesis, and intravasation. By modulating EMT, Ca2+ signaling can regulate the complexity and dynamics of events leading to metastasis. This review summarizes the role of Ca2+ signal remodeling in the regulation of EMT and metastasis in cancer.
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U2 - 10.1159/000512277
DO - 10.1159/000512277
M3 - Review article
AN - SCOPUS:85098220496
SN - 1422-6405
VL - 211
SP - 134
EP - 156
JO - Cells Tissues Organs
JF - Cells Tissues Organs
IS - 2
ER -
