TY - JOUR
T1 - The role of histone deacetylases in embryonic development
AU - Dsilva, Priyanka
AU - Pai, Padmini
AU - Shetty, Manasa Gangadhar
AU - Babitha, Kampa S.
N1 - Funding Information:
We would like to thank the Director, Manipal School of Life Sciences for all the support. The authors are grateful to DBT, the Government of India for providing DBT BioCare Fellowship. Authors thank TIFAC‐CORE, Department of Science and Technology, Government of India and Manipal Academy of Higher Education (MAHE), Manipal, India for infrastructure. This work was supported by the Department of Biotechnology (DBT) [Grant Number: BT/PR20046/BIC/101/683/2016], Government of India.
Funding Information:
We would like to thank the Director, Manipal School of Life Sciences for all the support. The authors are grateful to DBT, the Government of India for providing DBT BioCare Fellowship. Authors thank TIFAC-CORE, Department of Science and Technology, Government of India and Manipal Academy of Higher Education (MAHE), Manipal, India for infrastructure. This work was supported by the Department of Biotechnology (DBT) [Grant Number: BT/PR20046/BIC/101/683/2016], Government of India.
Publisher Copyright:
© 2022 Wiley Periodicals LLC.
PY - 2023/1
Y1 - 2023/1
N2 - The basic units of chromatin are nucleosomes, that are made up of DNA wrapped around histone cores. Histone lysine residue is a common location for posttranslational modifications, with acetylation being the second most prevalent. Histone acetyltransferases (HATs/KATs) and histone deacetylases (HDACs/KDACs) regulate histone acetylation, which is important in gene expression control. HDACs/KDACs regulate gene expressions through the repression of the transcription machinery. HDAC/KDAC isoforms play a major role during various stages of embryo development and neurogenesis. In specific, class I and II HDACs/KDACs are involved in cardiac muscle differentiation and development. An insight into different pathways and genes associated with embryonic development, the effect of HDAC/KDAC activity during the embryonic stem cell differentiation, preimplantation, embryo development, gastrulation, and the role of different HDAC/KDAC inhibitors during the process of embryogenesis is summarized in the present review article.
AB - The basic units of chromatin are nucleosomes, that are made up of DNA wrapped around histone cores. Histone lysine residue is a common location for posttranslational modifications, with acetylation being the second most prevalent. Histone acetyltransferases (HATs/KATs) and histone deacetylases (HDACs/KDACs) regulate histone acetylation, which is important in gene expression control. HDACs/KDACs regulate gene expressions through the repression of the transcription machinery. HDAC/KDAC isoforms play a major role during various stages of embryo development and neurogenesis. In specific, class I and II HDACs/KDACs are involved in cardiac muscle differentiation and development. An insight into different pathways and genes associated with embryonic development, the effect of HDAC/KDAC activity during the embryonic stem cell differentiation, preimplantation, embryo development, gastrulation, and the role of different HDAC/KDAC inhibitors during the process of embryogenesis is summarized in the present review article.
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U2 - 10.1002/mrd.23659
DO - 10.1002/mrd.23659
M3 - Review article
C2 - 36534913
AN - SCOPUS:85144304768
SN - 1040-452X
VL - 90
SP - 14
EP - 26
JO - Gamete Research
JF - Gamete Research
IS - 1
ER -