TY - JOUR
T1 - The transferred translocases
T2 - An old wine in a new bottle
AU - Balaji, S.
N1 - Funding Information:
The author acknowledges the grant (No. VGST/ GRD‐533/2016‐17/241) received from the Karnataka Science and Technology Promotion Society, India, for supporting the “Centre for Interactive Biomolecular 3D‐literacy” under the Vision Group on Science and Technology (VGST) scheme – Centres of Innovative Science, Engineering and Education.
Publisher Copyright:
© 2021 International Union of Biochemistry and Molecular Biology, Inc.
PY - 2022/8
Y1 - 2022/8
N2 - The role of translocases was underappreciated and was not included as a separate class in the enzyme commission until August 2018. The recent research interests in proteomics of orphan enzymes, ionomics, and metallomics along with high-throughput sequencing technologies generated overwhelming data and revamped this enzyme into a separate class. This offers a great opportunity to understand the role of new or orphan enzymes in general and specifically translocases. The enzymes belonging to translocases regulate/permeate the transfer of ions or molecules across the membranes. These enzyme entries were previously associated with other enzyme classes, which are now transferred to a new enzyme class 7 (EC 7). The entries that are reclassified are important to extend the enzyme list, and it is the need of the hour. Accordingly, there is an upgradation of entries of this class of enzymes in several databases. This review is a concise compilation of translocases with reference to the number of entries currently available in the databases. This review also focuses on function as well as dysfunction of translocases during normal and disordered states, respectively.
AB - The role of translocases was underappreciated and was not included as a separate class in the enzyme commission until August 2018. The recent research interests in proteomics of orphan enzymes, ionomics, and metallomics along with high-throughput sequencing technologies generated overwhelming data and revamped this enzyme into a separate class. This offers a great opportunity to understand the role of new or orphan enzymes in general and specifically translocases. The enzymes belonging to translocases regulate/permeate the transfer of ions or molecules across the membranes. These enzyme entries were previously associated with other enzyme classes, which are now transferred to a new enzyme class 7 (EC 7). The entries that are reclassified are important to extend the enzyme list, and it is the need of the hour. Accordingly, there is an upgradation of entries of this class of enzymes in several databases. This review is a concise compilation of translocases with reference to the number of entries currently available in the databases. This review also focuses on function as well as dysfunction of translocases during normal and disordered states, respectively.
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U2 - 10.1002/bab.2230
DO - 10.1002/bab.2230
M3 - Review article
AN - SCOPUS:85112613379
SN - 0885-4513
VL - 69
SP - 1587
EP - 1610
JO - Biotechnology and Applied Biochemistry
JF - Biotechnology and Applied Biochemistry
IS - 4
ER -