Abstract
The prominent theme of biomedical spectroscopy is early diagnosis and disease screening because it is critical for timely intervention and prevention. It is crucial in biomedical spectroscopy to identify and characterize biomolecules and continuously monitor their structural changes inside metabolically active cells and tissues. Vibrational Raman spectroscopy has gained an important position in biomedical spectroscopy due to its simplicity and high specificity compared to mass spectrometry and fluorescence spectroscopy. The accidental discovery and development of surface-enhanced Raman scattering in the 1970s also transformed Raman spectroscopy into a sensitive analytical tool, which now has achieved single-molecule detection capability. This chapter discusses the developments in theoretical and experimental aspects of surface-enhanced Raman spectroscopy over nearly five decades of its discovery and its application in biology and medicine. It also covers its prospects and challenges in live cell imaging.
| Original language | English |
|---|---|
| Title of host publication | Applied Raman Spectroscopy |
| Subtitle of host publication | Concepts, Instrumentation, Chemometrics, and Life Science Applications |
| Publisher | Elsevier |
| Pages | 57-76 |
| Number of pages | 20 |
| ISBN (Electronic) | 9780443218347 |
| ISBN (Print) | 9780443218354 |
| DOIs | |
| Publication status | Published - 01-01-2025 |
All Science Journal Classification (ASJC) codes
- General Chemistry