Tissue Reconstructive and Regenerative Medicine Approach as an Anti-Aging Intervention: Relevance to Age-Induced Osteoarthritis

Aging is a dynamic, irreversible, and inevitable physiological process associated with gradual deterioration in the overall performance of all the physiological system of human body. Everyone will undergo the process of aging, which makes the aged population more vulnerable to a plethora of age-associated disorders. One such prevalent disease is Osteoarthritis, which affects approximately 528 million people (as of 2019), and these numbers are predicted to increase as the population grows and ages. The progression of Osteoarthritis renders a great deal of pain and discomfort to the individual and limits their mobility significantly. This chapter contains four sections discussing the prevalence, causes, and prognostic options for age-induced Osteoarthritis. The underlying physical, biochemical, and molecular mechanisms leading up to the formation of an osteoarthritic joint are also explored. Furthermore, existing surgical, nonsurgical, and alternative treatment methods are discussed with an emphasis on the emergence of tissue reconstructive and regenerative medicine as a potential approach.