Abstract
Alzheimer's disease (AD) is the most prevalent form of dementia, and it is considered a dynamic cognitive decline. Neurofibrillary tangles and nerve cell injury are important neuropharmacological symptoms for one AD brain. TMP21 is an important molecule in cellular protein trafficking. TMP21, a protein involved in the production of neurotic plaques, appears to be dysregulated in AD. As a result, we want to look into TMP21 dysregulation in Alzheimer's disease, as well as the involvement of TMP21 in neurotic plaque development and the underlying mechanisms. TMP21's significance in the creation of neurofibrillary tangles, synaptic disbalance, and nerve cell death is also explored. It will shed light on the therapeutic potential of regulating TMP21 as a treatment for AD.
| Original language | English |
|---|---|
| Title of host publication | Enzymatic Targets for Drug Discovery Against Alzheimer's Disease |
| Publisher | Bentham Science Publishers |
| Pages | 73-92 |
| Number of pages | 20 |
| ISBN (Electronic) | 9789815136142 |
| ISBN (Print) | 9789815136159 |
| DOIs | |
| Publication status | Published - 29-12-2023 |
All Science Journal Classification (ASJC) codes
- General Medicine
- General Pharmacology, Toxicology and Pharmaceutics
- General Chemistry
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