TY - JOUR
T1 - Toward closed-loop drug delivery
T2 - Integrating wearable technologies with transdermal drug delivery systems
AU - Manikkath, Jyothsna
AU - Subramony, J. Anand
N1 - Funding Information:
The authors are thankful to AstraZeneca and Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India for support. Authors are also thankful to Deborah Shuman of AstraZeneca for editorial support.
Publisher Copyright:
© 2021
PY - 2021/12
Y1 - 2021/12
N2 - The recent advancement and prevalence of wearable technologies and their ability to make digital measurements of vital signs and wellness parameters have triggered a new paradigm in the management of diseases. Drug delivery as a function of stimuli or response from wearable, closed-loop systems can offer real-time on-demand or preprogrammed drug delivery capability and offer total management of disease states. Here we review the key opportunities in this space for development of closed-loop systems, given the advent of digital wearable technologies. Particular considerations and focus are given to closed-loop systems combined with transdermal drug delivery technologies.
AB - The recent advancement and prevalence of wearable technologies and their ability to make digital measurements of vital signs and wellness parameters have triggered a new paradigm in the management of diseases. Drug delivery as a function of stimuli or response from wearable, closed-loop systems can offer real-time on-demand or preprogrammed drug delivery capability and offer total management of disease states. Here we review the key opportunities in this space for development of closed-loop systems, given the advent of digital wearable technologies. Particular considerations and focus are given to closed-loop systems combined with transdermal drug delivery technologies.
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U2 - 10.1016/j.addr.2021.113997
DO - 10.1016/j.addr.2021.113997
M3 - Review article
AN - SCOPUS:85117162960
SN - 0169-409X
VL - 179
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
M1 - 113997
ER -