TY - JOUR
T1 - Toxic epidermal necrolysis and agranulocytosis
T2 - Rare adverse effects of ciprofloxacin
AU - Upadya, Gatha M.
AU - Ruxana, K.
PY - 2009/10/1
Y1 - 2009/10/1
N2 - Ciprofloxacin is one of the most commonly used antibacterial agents with relatively few side effects. Serious adverse reactions reported with ciprofloxacin are rare with an incidence of 0.6%. Recently we came across two rare adverse effects of ciprofloxacin, viz. toxic epidermal necrolysis and agranulocytosis. To our knowledge, a total of seven cases have been reported in the literature documenting an association between oral ciprofloxacin administration and toxic epidermal necrolysis. One case of granulocytopenia, four of pancytopenia and fifteen of leucopenia worldwide have been reported. With the use of ciprofloxacin becoming more and more widespread, these two rare but fatal complications of ciprofloxacin should be borne in mind.
AB - Ciprofloxacin is one of the most commonly used antibacterial agents with relatively few side effects. Serious adverse reactions reported with ciprofloxacin are rare with an incidence of 0.6%. Recently we came across two rare adverse effects of ciprofloxacin, viz. toxic epidermal necrolysis and agranulocytosis. To our knowledge, a total of seven cases have been reported in the literature documenting an association between oral ciprofloxacin administration and toxic epidermal necrolysis. One case of granulocytopenia, four of pancytopenia and fifteen of leucopenia worldwide have been reported. With the use of ciprofloxacin becoming more and more widespread, these two rare but fatal complications of ciprofloxacin should be borne in mind.
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U2 - 10.4103/0019-5359.57648
DO - 10.4103/0019-5359.57648
M3 - Article
C2 - 19901485
AN - SCOPUS:70450203378
SN - 0019-5359
VL - 63
SP - 461
EP - 463
JO - Indian Journal of Medical Sciences
JF - Indian Journal of Medical Sciences
IS - 10
ER -