TY - JOUR
T1 - Toxic epidermal necrolysis due to dapsone treatment in a patient with Hansen's disease - A case report
AU - Gupta, Sanjeev
AU - Palaian, Subish
AU - Chandradwari, Binayak
AU - Prabhu, Smitha
AU - Prabhu, Mukhyaprana
AU - Bista, Durga
AU - Mishra, Pranaya
PY - 2007/7/1
Y1 - 2007/7/1
N2 - Dapsone is a sulfone antimicrobial and is used widely as an antileprotic medication. The commonly encountered cutaneous adverse drug reactions (ADR) due to dapsone are exfoliative dermatitis, toxic erythema, erythema multiforme, morbilliform and scarlatiniform eruptions, urticaria, erythema nodusum and toxic epidermal necrolysis (TEN). We hereby report a case of toxic epidermal necrolysis caused due to dapsone. The causality, severity and preventability assessments were carried out. The patient was treated with systemic hydrocortisone, antibiotics and other symptomatic drugs. The reaction was severe and the patient expired on the second day of hospital admission in spite of the treatment. Since TEN is a life threatening cutaneous ADR and dapsone is a commonly used drug, this reaction needs monitoring.
AB - Dapsone is a sulfone antimicrobial and is used widely as an antileprotic medication. The commonly encountered cutaneous adverse drug reactions (ADR) due to dapsone are exfoliative dermatitis, toxic erythema, erythema multiforme, morbilliform and scarlatiniform eruptions, urticaria, erythema nodusum and toxic epidermal necrolysis (TEN). We hereby report a case of toxic epidermal necrolysis caused due to dapsone. The causality, severity and preventability assessments were carried out. The patient was treated with systemic hydrocortisone, antibiotics and other symptomatic drugs. The reaction was severe and the patient expired on the second day of hospital admission in spite of the treatment. Since TEN is a life threatening cutaneous ADR and dapsone is a commonly used drug, this reaction needs monitoring.
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M3 - Article
AN - SCOPUS:38649142174
SN - 1560-9014
VL - 17
SP - 195
EP - 199
JO - Journal of Pakistan Association of Dermatologists
JF - Journal of Pakistan Association of Dermatologists
IS - 3
ER -