TY - JOUR
T1 - Toxic epidermal necrolysis versus staphylococcal scalded skin syndrome
T2 - A diagnostic confusion in a 2-year-old child with ceftriaxone therapy
AU - Krishna, Vybhava
AU - Holla, Sadhana N.
AU - Sunny, Sweenly V.
AU - Hebbar, Srikiran A.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Toxic epidermal necrolysis (TEN) is a rare, but serious condition characterized by widespread death of epidermis involving skin and mucous membrane. Ceftriaxone-induced TEN in the pediatric age group is rare. Hereby, we present a child of 2 years, who was treated for food poisoning with ceftriaxone, amikacin, and ranitidine. The child developed generalized rash and hyperpigmentation with mucosal involvement. A diagnosis of staphylococcal scalded skin syndrome (SSSS) was considered initially, and ceftriaxone was advised to continue. Since the lesions aggravated and therapy was ineffective, ceftriaxone was discontinued. A diagnosis of ceftriaxone-induced TEN was made and treated symptomatically. The patient was discharged with complete recovery. Naranjo's algorithm showed a possible relationship with the adverse event. Ceftriaxone is generally considered safe in the pediatric population but still needs a watchful eye on the development of TEN as it closely resembles SSSS.
AB - Toxic epidermal necrolysis (TEN) is a rare, but serious condition characterized by widespread death of epidermis involving skin and mucous membrane. Ceftriaxone-induced TEN in the pediatric age group is rare. Hereby, we present a child of 2 years, who was treated for food poisoning with ceftriaxone, amikacin, and ranitidine. The child developed generalized rash and hyperpigmentation with mucosal involvement. A diagnosis of staphylococcal scalded skin syndrome (SSSS) was considered initially, and ceftriaxone was advised to continue. Since the lesions aggravated and therapy was ineffective, ceftriaxone was discontinued. A diagnosis of ceftriaxone-induced TEN was made and treated symptomatically. The patient was discharged with complete recovery. Naranjo's algorithm showed a possible relationship with the adverse event. Ceftriaxone is generally considered safe in the pediatric population but still needs a watchful eye on the development of TEN as it closely resembles SSSS.
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U2 - 10.4103/jpp.JPP_152_17
DO - 10.4103/jpp.JPP_152_17
M3 - Article
AN - SCOPUS:85050162702
SN - 0976-500X
VL - 9
SP - 46
EP - 48
JO - Journal of Pharmacology and Pharmacotherapeutics
JF - Journal of Pharmacology and Pharmacotherapeutics
IS - 1
ER -