Transethosome: An ultra-deformable ethanolic vesicle for enhanced transdermal drug delivery

Alan Raj, Kamal Dua, Rajesh Sreedharan Nair, C. Sarath Chandran, Angel Treasa Alex

Research output: Contribution to journalReview articlepeer-review


Drug delivery through the skin improves solubility, bioavailability, and unwanted systemic side effects of the drug. The selection of a suitable carrier is a challenging process. The conventional lipid vesicles have some limitations. They deliver the drug in the stratum corneum and have poor colloidal stability. Here comes the need for ultra-deformable lipid vesicles to provide the drug beyond the stratum corneum. Transethosomes are novel ultra-deformable vesicles that can deliver drugs into deeper tissues. The composition of transethosomes includes phospholipid, ethanol and surfactants. Each ingredient has a pivotal role in the properties of the carrier. This review covers the design, preparation method, characterisation, and characteristics of the novel vesicle. Also, we cover the impact of surfactants on vesicular properties and the skin permeation behaviour of novel vesicles.

Original languageEnglish
Article number105315
JournalChemistry and Physics of Lipids
Publication statusPublished - 09-2023

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Cell Biology


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