Transformative solidification techniques for self-emulsifying drug delivery and its foresight in modern-day drug delivery

Self-emulsifying drug delivery systems (SEDDSs) represent a significant breakthrough in addressing bioavailability challenges by enhancing the solubilization of poorly water-soluble drugs, ensuring consistent formulation properties, and facilitating easy industrial scale-up. Despite their liquid form posing some limitations, these challenges can be effectively addressed by solidifying SEDDSs, offering numerous advantages. The solidification of SEDDS has opened avenues for overcoming limitations associated with liquid formulations. Different approaches to solidification of SEDDS have been investigated to overcome the practical limitations of liquid formulations. Each method offers a plethora of benefits such as improved physiochemical stability, extended gastric residence time, controlled release of the drug, enhanced bioavailability, ease of handling, dose accuracy, and so on. While limitations persist, ongoing research is paving the path for the commercialization of solid SEDDS formulations with enhanced therapeutic effects. In light of previous publications, the current review paper makes an effort to give a comprehensive account of the most recent advancements in solid SEDDSs technology, with a focus on the formulation aspects of various types of novel solid self-emulsifying dosage forms for oral and nonoral drug delivery.