Translational approach utilizing COX-2, p53, and MDM2 expressions in malignant transformation of oral submucous fibrosis

Pratik N. Patel; Aatish Thennavan; Subhalakshmi Sen; Chetana Chandrashekar; Raghu Radhakrishnan

doi:10.2334/josnusd.57.169

Translational approach utilizing COX-2, p53, and MDM2 expressions in malignant transformation of oral submucous fibrosis

Pratik N. Patel, Aatish Thennavan, Subhalakshmi Sen, Chetana Chandrashekar, Raghu Radhakrishnan^*

^*Corresponding author for this work

Department of Oral Pathology, Manipal College of Dental Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

About 20% of the world’s population uses some form of betel nut, which suggests that the incidence of oral submucous fibrosis (OSF) is higher than current estimates. OSF has the potential to undergo malignant transformation; thus, there is a need to identify relevant markers to assess its aggressiveness. We evaluated changes in COX-2, p53, and MDM2 expressions in progressive OSF. Expressions of COX-2, p53, and MDM2 increased with OSF progression. There was a strong association between COX-2 overexpression and recurrence of oral squamous cell carcinoma (P < 0.001) and a positive relation between increased MDM2 expression and failure of radiotherapy (P = 0.007). These findings suggest that COX-2 is an important marker of disease progression and that MDM2 expression is useful for treatment planning.

Original language	English
Pages (from-to)	169-176
Number of pages	8
Journal	Journal of oral science
Volume	57
Issue number	3
DOIs	https://doi.org/10.2334/josnusd.57.169
Publication status	Published - 25-03-2015

All Science Journal Classification (ASJC) codes

General Dentistry

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abstract = "About 20% of the world{\textquoteright}s population uses some form of betel nut, which suggests that the incidence of oral submucous fibrosis (OSF) is higher than current estimates. OSF has the potential to undergo malignant transformation; thus, there is a need to identify relevant markers to assess its aggressiveness. We evaluated changes in COX-2, p53, and MDM2 expressions in progressive OSF. Expressions of COX-2, p53, and MDM2 increased with OSF progression. There was a strong association between COX-2 overexpression and recurrence of oral squamous cell carcinoma (P < 0.001) and a positive relation between increased MDM2 expression and failure of radiotherapy (P = 0.007). These findings suggest that COX-2 is an important marker of disease progression and that MDM2 expression is useful for treatment planning.",

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AU - Patel, Pratik N.

AU - Thennavan, Aatish

AU - Sen, Subhalakshmi

AU - Chandrashekar, Chetana

AU - Radhakrishnan, Raghu

PY - 2015/3/25

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Translational approach utilizing COX-2, p53, and MDM2 expressions in malignant transformation of oral submucous fibrosis

Abstract

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