Types of Raman Scattering Techniques for Neurodegenerative Diseases

Sparsha Kumari, Apoorva Bettagere Shivakumar, Sonam Fathima Mehak, Nirmal Mazumder, Gireesh Gangadharan, Vikram G. Pillai

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


As human life expectancy has increased, age-related neurodegenerative disorders (NDs) are emerging as one of the greatest health and social threats of the twenty-first century. Most NDs manifest clinical symptoms at an advanced stage after the disease onset, making it difficult to detect before irreversible degenerative alterations in the brain occur. As a result, understanding the neural mechanisms and early detection of ND are crucial for enhancing human health and quality of life. Raman spectroscopy and microscopy techniques allow for label-free, video-rate data acquisition without any sample preparation, making them a viable tool for disease detection early on. Raman-based approaches can be employed in vivo for early diagnosis of NDs as they are noninvasive. They require simple instrumentation and enable non-destructive sample analysis, which makes them useful for real-time diagnosis. Here, we outline the various Raman spectroscopic and microscopic techniques with a special focus on their application as a diagnostic tool for neurodegenerative diseases.

Original languageEnglish
Title of host publicationAdvances in Brain Imaging Techniques
PublisherSpringer Nature
Number of pages19
ISBN (Electronic)9789811913525
ISBN (Print)9789811913518
Publication statusPublished - 01-01-2022

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)


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