TY - JOUR
T1 - Use of convertible isocyanides for the synthesis of benazepril hydrochloride
AU - Borase, Bhushan B.
AU - Godbole, Himanshu M.
AU - Singh, Girij P.
AU - Upadhyay, Pritesh R.
AU - Trivedi, Anurag
AU - Bhat, Varadaraj
AU - Shenoy, Gautham G.
N1 - Funding Information:
The authors acknowledge Lupin Research Park and Manipal Academy of Higher Education for providing the opportunity to take up this research work. Thankful to Lupin Research Park, R& D, Analytical team for supporting the analysis.
Publisher Copyright:
© 2021, Indian Academy of Sciences.
PY - 2021/6
Y1 - 2021/6
N2 - Herein, we have described a novel and concise synthesis of the potent angiotensin-converting enzyme (ACE) inhibitor, benazepril hydrochloride (7) in trifluoroethanol via an Ugi three-component reaction in shorter reaction times. The key step is the trifluoroacetic acid-mediated hydrolysis of secondary amides (4a and 4b) followed by esterification as a domino process to form corresponding ethyl ester (6). Mainly two universal convertible isocyanides (1a and 1b) were used for the synthesis of benazepril hydrochloride. Graphic abstract: [Figure not available: see fulltext.] Synopsis: An efficient synthesis of benazepril hydrochloride using Ugi three-component reaction.
AB - Herein, we have described a novel and concise synthesis of the potent angiotensin-converting enzyme (ACE) inhibitor, benazepril hydrochloride (7) in trifluoroethanol via an Ugi three-component reaction in shorter reaction times. The key step is the trifluoroacetic acid-mediated hydrolysis of secondary amides (4a and 4b) followed by esterification as a domino process to form corresponding ethyl ester (6). Mainly two universal convertible isocyanides (1a and 1b) were used for the synthesis of benazepril hydrochloride. Graphic abstract: [Figure not available: see fulltext.] Synopsis: An efficient synthesis of benazepril hydrochloride using Ugi three-component reaction.
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U2 - 10.1007/s12039-021-01892-8
DO - 10.1007/s12039-021-01892-8
M3 - Article
AN - SCOPUS:85104095723
SN - 0974-3626
VL - 133
JO - Journal of Chemical Sciences
JF - Journal of Chemical Sciences
IS - 2
M1 - 35
ER -