Use of convertible isocyanides for the synthesis of benazepril hydrochloride

Bhushan B. Borase, Himanshu M. Godbole, Girij P. Singh, Pritesh R. Upadhyay, Anurag Trivedi, Varadaraj Bhat, Gautham G. Shenoy

Research output: Contribution to journalArticlepeer-review


Herein, we have described a novel and concise synthesis of the potent angiotensin-converting enzyme (ACE) inhibitor, benazepril hydrochloride (7) in trifluoroethanol via an Ugi three-component reaction in shorter reaction times. The key step is the trifluoroacetic acid-mediated hydrolysis of secondary amides (4a and 4b) followed by esterification as a domino process to form corresponding ethyl ester (6). Mainly two universal convertible isocyanides (1a and 1b) were used for the synthesis of benazepril hydrochloride. Graphic abstract: [Figure not available: see fulltext.] Synopsis: An efficient synthesis of benazepril hydrochloride using Ugi three-component reaction.

Original languageEnglish
Article number35
JournalJournal of Chemical Sciences
Issue number2
Publication statusPublished - 06-2021

All Science Journal Classification (ASJC) codes

  • Chemistry(all)


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