Vitamin D deficiency in patients with tuberculous meningitis and its relationship with treatment outcome

G. V. Dangeti, S. Mailankody, C. Neeradi, J. Mandal, R. Soundravally, N. M. Joseph, S. Kamalanathan, R. P. Swaminathan, T. Kadhiravan

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2 Citations (Scopus)


Setting: Data on Vitamin D deficiency in tuberculous meningitis (TBM) and its relationship with treatment outcomes are limited. Some of the beneficial effects of Vitamin D might be mediated through interleukin-1β (IL-1β). Objective: To assess the frequency of Vitamin D deficiency among TBM patients, its association with treatment outcomes and correlation between Vitamin D and IL-1β levels in cerebrospinal fluid (CSF). Design: We prospectively studied a consecutive sample of human immunodeficiency virus-negative patients with TBM treated at a hospital in southern India. We defined good outcome as survival without severe neurological disability. Serum total 25-hydroxy Vitamin D (25[OH]D) and IL-1β levels in CSF were estimated on pretreatment samples. Rwsults: We studied 40 patients with TBM; 22 (55%) patients had stage 3 disease. Treatment outcome was poor in 21 (53%) patients: 15 (38%) patients died and 6 (15%) had severe neurological disability. The overall mean serum 25(OH)D level was 32.30 × 16.38 ng/ml. Ten (25%) patients had Vitamin D deficiency (<20 ng/ml), and 12 (30%) patients had Vitamin D insufficiency (20-30 ng/ml). However, pretreatment serum 25(OH)D levels did not differ significantly by outcome (good vs. poor outcome: 28.30 × 14.96 vs. 35.92 × 17.11 ng/ml, P = 0.141). Moreover, IL-1β levels in CSF did not correlate with serum 25(OH)D levels (Spearman's ρ 0.083, P = 0.609). Conclusion: Vitamin D deficiency/insufficiency is common among patients with TBM. However, serum 25(OH)D levels are not associated with IL-1β levels in CSF or treatment outcome.

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalInternational Journal of Tuberculosis and Lung Disease
Issue number1
Publication statusPublished - 01-01-2018

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases


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