TY - JOUR
T1 - Wound healing property of ethanolic extract of leaves of Hyptis suaveolens with supportive role of antioxidant enzymes
AU - Shirwaikar, A.
AU - Shenoy, R.
AU - Udupa, A.L.
AU - Udupa, S.L.
AU - Shetty, S.
N1 - Cited By :40
Export Date: 10 November 2017
CODEN: IJEBA
Correspondence Address: Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal 576119, India; email: [email protected]
Chemicals/CAS: alcohol, 64-17-5; Antioxidants; Enzymes; Ethanol, 64-17-5; Plant Extracts
References: (1964) The Wealth of India (Raw Materials), 5, p. 159. , Council of Scientific and Industrial Reasearch, New Delhi; Kirtikar, K.R., Basu, B.D., (1991) Indian Medicinal Plants, 3, p. 2032. , Singh B & Sing M P Publishers, India; Chopra, R.N., Nayar, S.L., Chopra, I.C., (1986) Glossary of Indian Medicinal Plants, p. 44. , Council of Scientific and Industrial Reasearch, New Delhi; Harborne, J.B., (1998) Phytochemical Methods, p. 60. , Chapman and Hall, London; Kokate, C.K., (1994) Practical Pharmacognosy, p. 107. , Vallabh Prakashan, New Delhi; Ehrlich, H.P., Hunt, T.K., Effect of cortisone and anabolic steroids on tensile strength of a healing wound (1969) Ann Surg, 170, p. 203; Lee, K.H., Studies on the mechanism of action of salicylates II. Effect of vitamin A on wound healing retardation action of aspirin (1968) J Pharm Sci, 57, p. 1238; Morten, J.P., Malon, M.H., Evaluation of vulnery activity by an open wound procedure in rats (1972) Arch Int Pharmacodyn, 196, p. 117; Neuman, R.E., Logan, M.A., The determination of collagen and elastin in tissues (1972) J Biochem, 186, p. 549; Beauchamp, C., Fridovich, I., Superoxide dismutase: Improved assays and assay applicable to acrylamide gets (1972) Anal Biochem, 44, p. 276; Aebi, H., (1971) Methods of Enzymatic Analysis, 2, p. 674. , edited by H V Bergmeyer (Academic Press, New York); Aebi, H., (1971) Methods of Enzymatic Analysis, 3, p. 273. , edited by H V Bergmeyer (Academic Press, New York); Liu, F., Ooi, V.E.C., Chang, S.T., Free radical scavenging activites of mushroom polysaccharide extracts (1997) Life Sci, 60, p. 763; Devipriya, S., Shyamaladevi, C.S., Protective effect of quercetin in cisplatin induced cell injury in the kidney (1999) Indian J Pharmcacol, 31, p. 422
PY - 2003
Y1 - 2003
N2 - Ethanolic extract of leaves of Hyptis suaveolens was evaluated for its wound healing activity in ether-anaesthetized Wistar rats at two different doses (400 and 800mg/kg) using incision, excision, and dead space wound model. Significant increase in skin breaking strength, granuloma breaking strength, wound contraction, hydroxyproline content and dry granuloma weight and decrease in epithelization period was observed. A supportive study made on granuloma tissue to estimate the levels of catalase and superoxide dismutase recorded a significant increase in the level of these antioxidant enzymes. Granuloma tissue was subjected to histopathological examination to determine the pattern of lay-down for collagen using Van Gieson and Masson Trichrome stains. Enhanced wound healing activity may be due to free radical scavenging action of the plant and enhanced level of antioxidant enzymes in granuloma tissue. Better collagenation may be because of improved antioxidant studies.
AB - Ethanolic extract of leaves of Hyptis suaveolens was evaluated for its wound healing activity in ether-anaesthetized Wistar rats at two different doses (400 and 800mg/kg) using incision, excision, and dead space wound model. Significant increase in skin breaking strength, granuloma breaking strength, wound contraction, hydroxyproline content and dry granuloma weight and decrease in epithelization period was observed. A supportive study made on granuloma tissue to estimate the levels of catalase and superoxide dismutase recorded a significant increase in the level of these antioxidant enzymes. Granuloma tissue was subjected to histopathological examination to determine the pattern of lay-down for collagen using Van Gieson and Masson Trichrome stains. Enhanced wound healing activity may be due to free radical scavenging action of the plant and enhanced level of antioxidant enzymes in granuloma tissue. Better collagenation may be because of improved antioxidant studies.
M3 - Article
SN - 0019-5189
VL - 41
SP - 238
EP - 241
JO - Indian Journal of Experimental Biology
JF - Indian Journal of Experimental Biology
IS - 3
ER -